As NCI-H292 cells are also susceptible to infection by many strains of adenoviruses [21], including serotype 5, we considered NCI-H292 cells a good model to study the effect of E1A on IL-8 and IL-6 production, although we cannot exclude that the apparent contradictory results are due to the use epithelial cells from different origin. The gene discussed is CXCL8; the disease is infection.