The only gene that required atf-6 was cht-1, which encodes a chitinase ortholog of human chitotriosidase, an enzyme belonging to the family of glycosylhydrolases that is massively expressed by lipid-laden macrophages in different lipid-storage diseases including atherosclerosis and Gaucher disease [37,38]. The gene discussed is CHIT1; the disease is atherosclerosis.