The only gene that required atf-6 was cht-1, which encodes a chitinase ortholog of human chitotriosidase, an enzyme belonging to the family of glycosylhydrolases that is massively expressed by lipid-laden macrophages in different lipid-storage diseases including atherosclerosis and Gaucher disease [37,38]. This evidence concerns the gene SLC5A7 and Gaucher disease.