BRCA2 and breast carcinoma: King and colleagues recently reported that a healthy weight defined at menarche and at age 21, as well as physical activity during adolescence, were associated with a significant delay in the age of onset of breast cancer in BRCA1 and BRCA2 carriers; however, such an effect could be attributable to either weight gain increasing the risk of early-onset breast cancer or to weight gain protecting against late-onset breast cancer [4].