By univariate analysis of survival we found an inverse correlation between stromal HIF-1α overexpression (P = 0.032; Fig. 3), tumor grade (P = 0.039), stromal Ki67 overexpression (P = 0.028) and stromal p53 overexpression (P < 0.001) and disease-free survival, as presented in Table 4. This evidence concerns the gene TP53 and neoplasm.