HMGCS1 and metabolic syndrome: Transcripts encoding the enzymes that catalyze multiple steps in cholesterol synthesis were enriched in the macula, including stearoyl-CoA desaturase (SCD), mevalonate decarboxylase (MVD), hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), and HMG-coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the target of the 'statin' class of drugs for patients with dyslipidemia.