Stratifying by sex revealed that among men, the LEP 19AA genotype was associated with a reduced risk of NHL (OR=0.6, 95% CI 0.4–1.0, P=0.06) and FL (OR=0.3, 95% CI 0.1–0.7, P=0.005), while the LEP −2548AA genotype was associated with an increased risk of NHL (OR=1.6, 95% CI 1.1–2.5, P=0.02), DLBCL (OR=1.6, 95% CI 1.0–2.7, P=0.07) and FL (OR=1.8, 95% CI 0.9–3.5, P=0.10). Here, LEP is linked to diffuse large B-cell lymphoma.