Furthermore, polymorphisms in the LEP (an A to G nucleotide (nt) change at position 19 in the 5′-untranslated region (Hager et al, 1998), and a G to A substitution at nt −2548 upstream of the ATG start site (Mammes et al, 1998)) and LEPR (an A to G transition at nt 668 from the start codon that converts glutamine to arginine at codon 223 (223Q>R) (Gotoda et al, 1997)) genes were recently shown to modulate NHL risk (Skibola et al, 2004). The gene discussed is LEP; the disease is non-Hodgkin lymphoma.