LEP and obesity due to melanocortin 4 receptor deficiency: The risks associated with the variant genotypes did not increase with rising grades of obesity; for example, the risk of NHL did not incline among persons carrying the LEP −2548AA genotype with increasing weight-for-height, from normal weight (OR=1.3, 95% CI 0.9–2.0, P=0.19), through grade 1 overweight (OR=1.5, 95% CI 0.9–2.5, P=0.09), to grades 2 and 3 overweight (OR=0.9, 95% CI 0.3–2.5, P=0.88).