In the absence of measured plasma levels before the diagnosis of NHL, long-term variation in production of these adiponectins may be indicated by the polymorphisms investigated here, since the LEP 19G, LEP −2548A and LEPR 223R alleles have been associated with elevated leptin levels, and the APM1 276T allele with lower adiponectin levels (Hoffstedt et al, 2002; van Rossum et al, 2003; Filippi et al, 2004). This evidence concerns the gene LEPR and non-Hodgkin lymphoma.