In regards to HBV infection, the Asian-Pacific Association for the Study of the Liver (APASL), the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) recommend treating patients who have moderate to severe chronic hepatitis as evidenced by >2-fold elevation of ALT levels or significant findings on liver biopsy associated with HBV DNA >105 copies/mL. Here, GPT is linked to chronic hepatitis.