TP53 and neoplasm: It is possible that eEF1A2 is not upregulated in tumours with p53 mutations because wild-type p53 is required for expression of eEF1A2 in certain cell types; it has been shown that p53 can upregulate expression of eEF1A1 [11], and the p53 binding sites identified in the gene encoding eEF1A1 are shared with that encoding eEF1A2 (unpublished observations).