In summary, out of 17 cases with histologic follow-up 4/17 (24%) were reactive with CD4/CD8 ratio of 4.1–29, 7/17 (41%) were HLs with CD4/CD8 ratio of 5.3 – 11, and 6/17 (35%) were NHLs with CD4/CD8 T-cell ratio of 4.2 – 14. This evidence concerns the gene CD4 and Hydrolethalus.