In addition, the lack of observed ICHs during DrotAA infusion and an ICH rate of 2.5% during the study period for pediatric patients with PF, MEN, or MD are particularly interesting in view of a recent study of recombinant tissue plasminogen activator treatment in children with meningococcal PF (reported ICH rate 8%; 5 of 62) [52]. The gene discussed is PLAT; the disease is pemphigus foliaceus.