Tables 1, 2 and 3 show that there was an even distribution of known prognostic factors such as age, tumour size, malignancy grade, hormone receptor status and positive lymph nodes across the four strata of initiation of chemotherapy within the three groups of chemotherapy, with the exception of patients treated early with CMF i.v. being more likely to be node positive and more likely to be receptor positive than those treated later (Table 2). Here, NR4A1 is linked to neoplasm.