The tumour biological importance of FAK was confirmed by experiments targeting pp125FAK with antisense oligonucleotides leading to an inhibition of cell migration, invasion and proliferation as well as an induction of apoptosis and enhanced sensitivity to campothecins (Hungerford et al, 1996; Golubovskaya et al, 2002; Satoh et al, 2003). Here, PTK2 is linked to neoplasm.