IL2 and Thrombocytopenia: Table 3 lists grade 3/4 toxicity to treatment. There was generally more reported toxicity among the Danish patients compared with the UK patients. Concerning nausea and vomiting, the toxicity was more pronounced in the UK study. However, toxicity was not significantly different for IL-2-alone compared with IL-2 plus HDC in either of the studies. In total, only three of the 104 patients had grade 4 toxicity (lethargy, Escherichia coli sepsis and thrombocytopenia/bowel infarction, respectively).