In addition to the primary measures, we measured plasma vitamin B12, since homocysteine concentration can depend on its concentration (Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, 1999), thiamin, as experimental studies suggest that thiamin deficiency can result in the formation of endogenous α-oxoaldehydes and the induction of colon cancer (Bruce et al, 2003), and C-reactive protein, since it provides a more general assessment of inflammation than faecal calprotectin and is itself associated with colon cancer risk (Erlinger et al, 2004). Here, CRP is linked to malignant colon neoplasm.