The JACC Study for Evaluation of Cancer Risk, sponsored by the Ministry of Education, Science, Sports, and Culture of Japan (Monbusho), was conducted to collect information from 110,792 subjects and sera from 39,242 subjects, aged from 40 to 79 years, in 45 districts of Japan from 1988 to 1990.12 In the present study, we investigated effects of serum CRP, which is a biomarker of inflammation and has recently been suggested to play a role in risk of colorectal cancer, using sera collected in the JACC Study. The gene discussed is CRP; the disease is colorectal cancer.