Wakai et al.7 analyzed the dataset for lung cancer and found smaller ORs with higher levels of IGF-II and IGFBP-3; the ORs over quartiles were 1.00, 0.41, 0.47, and 0.67 for IGF-II (trend p = 0.018) and 1.00, 0.55, 0.54, and 0.67 for IGFBP-3 (trend p = 0.037). The gene discussed is IGFBP3; the disease is lung carcinoma.