The significant associations between serum IGF-I, II, or IGFBP-3 and stomach cancer have been observed in the previous studies dealing with disease patients and their controls.15,16 We did not, however, find any significant differences in IGFs levels between cases and controls, suggesting the alterations observed in the previous studies might be due to existing tumors. The gene discussed is IGFBP3; the disease is gastric neoplasm.