GAD2 and pancreatic insulinoma: In addition to the aforementioned genetic results, Boutin et al. [18] also found that luciferase reporter genes containing the −243 G allele in the GAD2 promoter (from −1710 to −4, relative to the transcriptional start site) displayed a 6-fold higher activity compared to reporter genes containing the −243A allele in βTC3 murine insulinoma cells (Figure 3 in [18]).