The prognostic significance of AAT expression in lung adenocarcinomas has been evaluated using immunohistochemistry [47]; strongly AAT-positive cases had a worse prognosis than weak-to-moderately AAT-positive or AAT-negative cases, suggesting that increased AAT expression in lung adenocarcinoma patients may be a prognostic indicator. The gene discussed is SERPINA1; the disease is lung adenocarcinoma.