Systemic hypertension, diabetes mellitus and hyperlipidaemia have long-established, but complex, patterns of inheritance, a situation further compounded by evidence receptor polymorphisms – including those of angiotensin II type 1 receptor [120], IRS-1 gene [121] and low density lipoprotein receptor (LDLR) [122] – both confer disease susceptibility and have regionally variable prevalences [123, 124]. The gene discussed is LDLR; the disease is Hypertension.