PGR and breast cancer: By considering loadings and signs in the first solution, patients with higher NHG, higher S-phase fraction, presence of lymph node involvement (based on pathology reports and physical examination), presence of periglandular growth, larger tumor size, negative estrogen and progesterone receptor status, DNA aneuploidy and abnormal DNA index are associated with an increased risk for distant metastasis (DM) and loco-regional recurrence (LRR) during the first two years after diagnosis of breast cancer, and DM 2–4 years after diagnosis.