However, the binding experiments suggested that SIR by FV Env is similar to SIR by other retroviruses, whereby high expression of FV Env in stably transfected cell lines led to a complete resistance to FV SU-Ig binding and FV permissiveness, and low expression of FV Env led to a decreased susceptibility to infection and a lowered FV SU-Ig binding [44]. The gene discussed is ERVW-1; the disease is infection.