In the case of cylindromatosis (CYLD),calcitonin gene-related peptide-receptor component protein (RCP9), LIM protein (LIM), occludin (OCLN), Rho-associated, coiled-coil containing protein kinase 1 (ROCK1), and zinc finger, CCHC domain containing 4 (ZCCHC4), the microarray results showed that these genes were down-regulated in both IBD subtypes, but failed to reach significance in the UC cohort. The gene discussed is ZCCHC4; the disease is irritable bowel syndrome.