Up-regulated genes in the UC profile included v-myb myeloblastosis viral oncogene homolog 2 (MYBL2,Table 3) and several members of the S100 protein family, whose expression has been reported to promote cell proliferation and are linked with increased malignancy or tumour progression in colon cancer [42–45]. The gene discussed is MYBL2; the disease is malignant colon neoplasm.