In five patients, a single cancer demonstrated MSI-H and the other showed MSI-L/MSS; one lost MLH1 expression in both cancers, one showed loss of MLH1 expression in the MSI-H cancers but not in the MSI-L/MSS cancer, while three patients expressed MLH1, MSH2 and MSH6 in both cancers. The gene discussed is MSH2; the disease is cancer.