Of nine MSI-H cancers, six failed to express MLH1, one failed to express MSH2, and two expressed MLH1 and MSH2. One of the MSI-L/MSS cancers failed to express MSH2 and the remaining 45 expressed both MLH1 and MSH2. All 55 cancers expressed MSH6 (Table 3). The gene discussed is MSH6; the disease is cancer.