Although SDHB mRNA was collectively lower in Cluster 1 tumors than in Cluster 2 pheochromocytomas (Dataset S5), levels of the SDHB protein did not exactly parallel mRNA abundance in individual tumor samples, suggesting that a transcription defect cannot entirely account for the differences in SDHB expression observed at the protein level. The gene discussed is SDHB; the disease is hereditary pheochromocytoma-paraganglioma.