HLA-DRB1 and chronic beryllium disease: Previous studies have identified the HLA-DRB1 alleles belonging to the *01 group [13] as negatively associated with berylliosis, while the HLA-DRB1 variants Ser11 [12], Tyr26 [10], Asn37 [12], Glu71 [12] and Arg74 [10] and the HLA-DQ variant Gly86 [12] were positively associated with BH.