Thus this gene over expression or may be the protein over expression can be used to detect the cancer at the early stage or at HCC and hence it may be considered as a future diagnostic means for detection of hepatic cancer and its stages and IGFII gene 33 expression could be considered as one of the best positive markers for early detection of putative preneoplastic cell as well as HCC in chemically induced hepatocarcinogenesis. This evidence concerns the gene IGF2 and cancer.