KLK3 and prostate carcinoma: If tests are to be developed that will allow the prediction of clinical behaviour of patients diagnosed with prostate cancer, for example, following prostate-specific antigen (PSA) screening, it must be possible to perform the test on biological specimens obtained from the patients at the time of diagnosis, which would usually only include trans-rectal ultrasound (TRUS)-guided needle biopsy specimens, blood or urine.