Overexpression of cyclin A has been associated with worse prognosis for breast cancer in several studies (Bukholm et al, 2001; Michalides et al, 2002; Michels et al, 2002), but the results have not been consistent (Kuhling et al, 2003; Rudolph et al, 2003). This evidence concerns the gene CCNA2 and breast carcinoma.