In this study, we investigated the immunohistochemical expressions of TGF-β1 and p27 in pancreatic adenocarcinomas and the results were correlated with the clinicopathologic characteristics of the cases and the patients' survival to find out if these factors could be used as an additional predictor of the disease extent and patient outcome. This evidence concerns the gene TGFB1 and pancreatic adenocarcinoma.