PRAME and melanoma: Several genes not previously known to be upregulated by hypoxia included Ribonuclease 4 RNAse4 3.1-fold, monocarboxylate transporter family member 4 (SLC16A3 also called MCT4), Preferentially expressed antigen of melanoma PRAME 4.9-fold and Importin Beta 3 4.1-fold.