The chemokines CXCL1 (Gro-α) and CXCL8 (IL-8) are constitutively produced by melanoma cells and the corresponding receptors CXCR1 and CXCR2 are expressed on melanoma cells as well as on macrophages, neutrophils and eosinophils (Moser et al, 1993; Norgauer et al, 1996; Dhawan and Richmond, 2002). The gene discussed is CXCR1; the disease is melanoma.