Ang I also mediates the same effects through conversion to Ang II by ACE, since the ACE inhibitor imidaprilat, the active metabolite of imidapril, in which an ethyl ester group is hydrolysed (Mabuchi et al, 1999), attenuates the action of Ang I. There is also evidence to suggest that formation of Ang II may contribute to the loss of body tissue in mice bearing the MAC16 tumour, since imidapril attenuated the development of weight loss in this model. This evidence concerns the gene AGT and neoplasm.