We analyzed the presence of elevated titers of anti-Ro, anti-La, anti-RNP,anti-Sm, anti-Jo1, anti-centromere, anti-Scl-70, anti-histone, and anti-dsDNAantibodies in 199 serum samples (113 SLE patients, 86 healthy donors). Here, SSB is linked to systemic lupus erythematosus.