Only co-culture with RCC-26 cells, but not with autologous LCL-26, the normal kidney cell line (NKC-26), or the HLA-A*0201-matched tumor cell line RCC-53 induced IFNγ-release, indicating that only RCC-26 cells provided the specific ligand for TIL-26 activation (Figure 5A). Here, IFNG is linked to renal cell carcinoma.