Before the discovery of HFE, it was reported that inheritance of part or all of the hemochromatosis ancestral haplotype that includes HLA-A*03 and -B*07, particularly in a homozygous configuration, was associated with evidence of more severe iron overload in hemochromatosis patients in Australia, Alabama, and Italy [24-26]. The gene discussed is HLA-A; the disease is Tangier disease.