In the present study, we performed multivariate analyses of the variables sex; age; transferrin saturation and serum ferritin concentration at diagnosis; units of blood removed by phlebotomy to achieve iron depletion; and human leukocyte antigen (HLA)-A and -B alleles and haplotypes to determine their effects on total blood lymphocyte count at diagnosis in hemochromatosis probands with C282Y homozygosity. Here, HLA-A is linked to hemochromatosis type 1.