Recent studies with BAL in scleroderma patients have shown that a subset of them, who present more than 15% lymphocytes in BAL [38], or have activated, long-lived CD8+ T cells [40], or produce type 2 cytokines (IL-4 and IL-5) by the CD8+ TLs [39], present a more aggressive form of interstitial pneumonia. This evidence concerns the gene CD8A and scleroderma.