To this end Iyonaga et al. [118] in parallel with the elevation of MCP-1 serum levels in sarcoid individuals and their linkage with radiographic abnormalities showed by both immunohistochemistry and in situ hybridization that the origin of the increased MCP-1 plasma levels were the macrophages peripheral to the granulomas suggesting a role for this molecule as an indicator in estimating the activity of granuloma formation and subsequently of the sarcoidosis activity. The gene discussed is CCL2; the disease is Granuloma.