The accumulated data provide particular support for DISC1, DTNBP1, NRG1, and RGS4. Each of these genes has received support from multiple lines of evidence with imperfect consistency: 1) The case for each of these as a candidate gene for schizophrenia is supported by linkage studies; 2) The preponderance of association study findings provides further support; 3) mRNA from each gene is expressed in the prefrontal cortex as well as in other areas of the brain; and 4) Additional neurobiological data link the functions of these genes to biological processes thought to be related to schizophrenia. The gene discussed is DISC1; the disease is schizophrenia.