The cagA was positive in three cases (27.3%) of mild gastritis, seven (15.9%) moderate to marked gastritis, 23 (71.9%) gastric ulcer, two (50%) atrophic gastritis, one with and one without intestinal metaplasia, and four (100%) adenocarcinoma (p < 0.0001). This evidence concerns the gene S100A8 and adenocarcinoma.