The findings that cyclin D3 was uniquely overexpressed in only one of the 57 cases (Table 1) and that in a subset of tumours cyclin D3 protein expression was reduced as compared to normal tissue (Figure 3C) support the notion that cyclin D3 plays an important role in the differentiation of colon epithelial cells but not in colon carcinogenesis. Here, CCND3 is linked to neoplasm.