Cyclin D1 overexpression has been reported to occur in 40–70% of colon tumours (Arber et al, 1996, 1999; Sutter et al, 1997; Bukholm and Nesland, 2000; Kristt et al, 2000; Holland et al, 2001; Utsunomiya et al, 2001). The gene discussed is CCND1; the disease is colonic neoplasm.