TP53 and urinary bladder neoplasm: In cytological samples, p53 overexpression has been shown to have only 23.5% sensitivity and 75.0% specificity in detecting bladder tumours (Righi et al, 1997), but in other series, sequence analysis of voided urine specimens compared with tissue samples showed 84.2% sensitivity and 96.8% specificity (Prescott et al, 2001).