Experimental and clinical data had indicated that EGFR over expression correlated with various critical processes in the development, maintenance, and spread of malignant tumors.[30] The reduction of EGFR may lead to a failure in downstream signal cascades including PI3-K, RAS-RAF-MAPK P44/P42, and protein kinase C pathway, and subsequently block the routes to activation of more direct modulators of mitogenesis and other cancer-promoting phenotypes [13]. Here, EGFR is linked to cancer.