NFKB1 and breast carcinoma: Table 2 shows that the most significant transcription factor in the breast cancer data set of van 't Veer et al. is NF-κB. This transcription factor is also the most one in the leukemia data set of Golub et al., whereas NF-κB1 is the most significant one in the data set of Sotirou et al Recently, NF-κB has been shown to be involved in the transformation from benign to malignant cells in inflammation-associated cancers.