Similarly, increased cellular infiltration and increased expression of E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, platelet/endothelial cell adhesion molecule-1, very late appearing antigen-4, and Mac-1 were found in immunohistochemistry of synovial tissue from patients with RA [24]. The gene discussed is ICAM1; the disease is rheumatoid arthritis.