One of these was an 82-year-old man who presented with a 6-week history of synovitis (RF negative, anti-CCP antibody negative, CRP 51 mg/l); the other was a 70-year-old woman who presented with a 10-week history of synovitis (RF positive, anti-CCP antibody positive, CRP 25 mg/l). Here, CRP is linked to synovitis.