For instance, loss of E-cadherin in bladder, prostate, breast and colorectal cancers, or integrins such as α2β1 and α5β1 in breast cancer and α6β1 in melanoma cells correlates with increased malignancy of tumor cells, indicating that the integrity of the primary tumor depends on signals from adjacent cells and from appropriate extracellular matrix ligands [1,2,5-8]. This evidence concerns the gene CDH1 and neoplasm.