Foulkes and colleagues [21] also recently reported that the proportion of ER+ tumours increased with patients' age among the BRCA1 patients included in their study (diagnosed at less than 65 years of age), although they found a strong relationship between BRCA1 carrier status and ER-negativity of tumours in the age group 55 to 65 years. The gene discussed is BRCA1; the disease is neoplasm.