In BRCA2 families, tumours of patients diagnosed at less than 50 years of age differed significantly from those of the older patients for ER-negativity (20.6% vs 52.6%, respectively, P = 0.017) and PR-receptor negativity (35.3% vs 80.0%, P = 0.001) (Table 1). Here, BRCA2 is linked to neoplasm.