CSF3 and Decreased total neutrophil count: The commonest combinations have been irinotecan given concurrently with etoposide (Karato et al, 1993; Masuda et al, 1994; Oshita et al, 1997; Masuda et al, 1998), in which the DLTs were typically neutropenia and diarrhoea, and required G-CSF support.