CD4 and cancer: This is in agreement with some reports (de Gruijl et al, 1996a, 1996b, 1998; de Jong et al, 2004), but not others, where CD4 responses have been found to be decreased in cancer (Luxton et al, 1996, 1997; Nakagawa et al, 1996; Hopfl et al, 2000; van der Burg et al, 2001; Welters et al, 2003).